How Long Does Nicotine Stay in Your Blood and Body by RedOrbit Nicotine is one of the most addictive substances, which makes smoking a habit that’s notoriously hard to shake. And even if one manages to quit, traces of the substance will still be present in one’s system days after going cold turkey. E-cigarettes are considered a less harmful alternative to conventional cigarettes. However, e-cigarette cartridges contain as much as 21 to 85% nicotine. The body won’t know the difference so it will absorb the nicotine just the same. So, how long does nicotine stay in your blood and body? To get the answer, you should take a closer look at the way and rate the human body absorbs this dangerous toxin. Smoking and Nicotine Ingestion Tobacco companies make sure to provide a variety of cigarettes to suit individual nicotine addicts. On average, a single cigarette has 12 milligrams of nicotine, about 1 milligram of which reaches the bloodstream. Once inside the bloodstream, nicoti...