Why You’re Not Supposed to Drink on Antibiotics by Refinery29 You were responsible enough to go to the doctor and get antibiotics for your pesky urinary tract infection, but you also have a happy hour tonight that you do not want to miss. Technically, you're not "supposed to" drink when you're taking antibiotics, but what's the worst thing that could happen if you crack open a cold one tonight? You might have heard from a well-meaning friend that drinking on antibiotics just "makes you get drunker, faster," but it's actually more complex than that. There are two main reasons why you should avoid alcohol while on a course of antibiotics: There's potential for increased side effects, and the alcohol could interact with the drug's ability to do its job, explains Stephen Ferrara, RN, DNP, RNC-BC, associate dean for clinical affairs at Columbia University School of Nursing, who oversees its faculty practice, ColumbiaDoctors Primary Care Nu...