What to know about sleeping with earplugs Reviewed by Aaron Kandola & Deborah Weatherspoon, PhD, RN, CRNA Earplugs are generally safe to use while sleeping. However, it is possible that frequent use can lead to some minor problems in the long run, such as earwax buildup. Sometimes, noise from the environment can disrupt sleep. For example, having a bedroom that faces a busy street can affect sleep duration. However, disrupted sleep may also be a problem when trying to sleep in different environments, such as on a plane. Earplugs can significantly reduce the amount of sound entering the ears, which may help people get to sleep in noisy environments. This article will discuss the safety of earplugs and the benefits they can provide. Safety Using earplugs while sleeping can block out surrounding noises. Using earplugs is a great way to block out surrounding noises that can disturb a natural sleep pattern. Not all noises have a negative effect on sleep. For exa...